What is EDTA

Disodium edetateAuxiliary materialsSodium edetate is the disodium salt of EDTA. It is a complexing agent that forms stable complexes with various metal ions. Sodium edetate is used as an adjuvant primarily for liquid and semi-solid medicinal forms. By inactivating the metal ions, it has conserving and stabilizing effects.

synonymous: Dinatrii edetas, disodium edetate, Na-EDTA


Sodium edetate is contained in many pharmaceuticals as an auxiliary substance, especially in liquid and semi-solid pharmaceutical forms.

Structure and properties

Disodium edetate (C.10H14N2N / A2O8 · H2O, Mr = 372.2 g / mol) is a white, crystalline powder and is soluble in water. It is the disodium salt of EDTA, the edetic acid.


Sodium edetate has complexing, preserving, clarifying, stabilizing and anticoagulant properties. It forms stable complexes with various metals, for example with calcium, magnesium and zinc. Among other things, it inhibits their catalytic activity and the reproduction of bacteria that depend on them.

application areas

As a complexing agent and stabilizer for the manufacture of pharmaceuticals.

  • Medicinal product information (CH)
  • European Pharmacopoeia PhEur
  • Specialist literature
  • Pharmaceutical Technology Textbooks

Conflicts of Interest: None / Independent. The author has no relationships with the manufacturers and is not involved in the sale of the products mentioned.

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This article was last changed on 9/6/2020.
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